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T8239 |
Cromoglicic acid
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Others
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|
Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells. |
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T9926 |
Omalizumab
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Others
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|
Omalizumab is a recombinant humanized monoclonal antibody against human immunoglobulin E IgE) |
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T9043 |
AS1810722
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|
P450
,
STAT
|
|
AS1810722, a fused bicyclic pyrimidine derivative, is an orally active and potent inhibitor of STAT6, demonstrating an IC50 of 1.9 nM. It exhibits effective inhibition of CYP3A4, positioning it as a promising candidate f... |
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T0211 |
Azelastine
|
Azelastina,Astelin,Azelastinum |
SARS-CoV
,
Histamine Receptor
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|
|
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T5310 |
TR-14035
|
MDK-1191 |
Integrin
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|
TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM). |
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T0211L |
Azelastine hydrochloride
|
Optivar,Azelastine HCl,Allergodil,Astelin |
SARS-CoV
,
Histamine Receptor
|
|
Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity. |
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T0188 |
Fluticasone (propionate)
|
CCI-187881,Fluticasone propionate |
Glucocorticoid Receptor
,
Virus Protease
,
Estrogen/progestogen Receptor
,
Phospholipase
,
Endogenous Metabolite
|
|
Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist. |
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T15666 |
KP136
|
AL136 |
Histamine Receptor
|
|
KP136 (AL136) is an orally active anti-allergic compound that inhibits histamine release and is used in studies of asthma and allergic edema. |
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T2270 |
Trans-Tranilast
|
Tranilast trans- |
RAAS
|
|
Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993.... |
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T15772 |
Lodoxamide tromethamine
|
U-42585E |
Histamine Receptor
|
|
Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic conjunctivitis. |
|
T1030 |
Triprolidine hydrochloride monohydrate
|
Triprolidine hydrochloride |
Histamine Receptor
|
|
Triprolidine hydrochloride monohydrate is a histamine H1 antagonist used in allergic rhinitis, asthma. |
|
T2392 |
Nafamostat mesylate
|
FUT-175 |
Apoptosis
,
Serine/threonin kinase
,
SARS-CoV
,
Serine Protease
|
|
Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. |
|
T1531 |
Mometasone furoate
|
Sch32088 |
Glucocorticoid Receptor
|
|
Mometasone furoate (Sch32088) is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for ski... |
|
T68128 |
Picumast
|
|
|
|
Picumast shows antiallergic activity and can be utilized in the treatment of asthma. Picumast may be used in the treatment of therapeutic allergic airway diseases. |
|
T83168 |
Aderamastat
|
FP-003,FP-025 |
MMP
|
|
Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor indicated for the study of allergic asthma, COPD and pulmonary fibrosis. |
|
T14377 |
AZD5423
|
|
Glucocorticoid Receptor
|
|
AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma. |
|
T1553 |
Chlorpheniramine maleate
|
NCI-C55265,Chlorphenamine maleate |
Histamine Receptor
|
|
Chlorpheniramine maleate (NCI-C55265) is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. |
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T4566 |
Lodoxamide
|
Lodoxamidum |
GPR
,
Histamine Receptor
|
|
Lodoxamide (Lodoxamidum) is an antiallergic drug acting as a mast-cell stabilizer. It is effective in the treatment of asthma and allergic conjunctivitis. |
|
T2396 |
Ramatroban
|
BAY u3405 |
GPR
,
Prostaglandin Receptor
,
PPAR
|
|
Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma. |
|
T11581 |
HSR6071
|
|
Others
|
|
|
|
T10208 |
A-69412
|
N-1-(Fur-3-ylethyl)-N-hydroxyurea |
Lipoxygenase
|
|
A-69412 (N-1-(Fur-3-ylethyl)-N-hydroxyurea) is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other inflammatory and allergic... |
|
T1278 |
Astemizole
|
Laridal,Histaminos,Paralergin |
Potassium Channel
,
Histamine Receptor
|
|
Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to re... |
|
T0089 |
Cetirizine dihydrochloride
|
P071,UCB P071,Cetirizine DiHCl |
Histamine Receptor
|
|
Cetirizine dihydrochloride (UCB P071) is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, and pollen-induced asthma. Unlike other conventiona... |
|
TP2008L |
Lyn peptide inhibitor acetate
|
Lyn peptide inhibitor acetate(222018-18-0 free base) |
IL Receptor
|
|
Lyn peptide inhibitor acetate is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the bind... |
|
T10437 |
AZD8848
|
|
TLR
|
|
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis. |
|
T21112 |
Triprolidine hydrochloride
|
295 C 51,Pro-Entra,Entra,Actidilat,Triprolidine hydrochloride anhydrous,Actidil,Pro-Actidil |
|
|
Triprolidine hydrochloride anhydrous, a Histamine H1 antagonist, is used in asthma, allergic rhinitis, and urticaria. |
|
T26582 |
AIM-102
|
|
|
|
AIM-102, a nonsteroidal, immune modulating, anti-inflammatory drug, is used potentially for the treatment of allergic asthma. |
|
T26628 |
Andolast
|
CR2039,CR-2039,CR 2039 |
|
|
Andolast, also known as CR-2039, an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast acts at different cellular levels to inhibit immunoglobulin E synthesi... |
|
T68620 |
(R)-DOI hydrochloride
|
|
|
|
(R)-DOI hydrochloride is a 5-HT2 receptor agonist, inhibiting TNF-α-mediated proinflammatory signaling cascades and inflammation via 5-HT2A receptor activation and preventing the development of, and inflammation associat... |
|
T80131 |
C5a Anaphylatoxin (human)
|
|
Complement System
|
|
C5a Anaphylatoxin (human) is a pro-inflammatory peptide that functions as a leukocyte chemoattractant, utilized in researching inflammation and immune responses, including allergic asthma [1] [2]. |
|
T37386 |
Dihydro Montelukast
|
|
|
|
Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast (sodium salt) is a potent and selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist. Formulations containing ... |
|
T68280 |
Adriforant
|
|
|
|
Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of ... |
|
T60590 |
Chloropyramine
|
|
|
|
Chloropyramine is a competitive reversible H1 receptor antagonist that can be used in allergic conditions research, for example, conjunctivitis and bronchial asthma. Chloropyramine also shows anti-tumour activity in brea... |
|
T69918 |
Adriforant tartrate hydrate
|
|
|
|
Adriforant tartrate hydrate, also known as ZPL-3893787 tartrate hydrate, PF-3893787 tartrate hydrate and ZPL-389 tartrate hydrate, is a novel histamine H4 receptor antagonist. Adriforant tartrate hydrate shows an excelle... |
|
T71329 |
Theophylline-d6
|
|
|
|
Theophylline-d6 is intended for use as an internal standard for the quantification of theophylline by GC- or LC-MS. Theophylline is an inhibitor of phosphodiesterase. It is also an adenosine A1 and A2 receptor antagonist... |
|
T64013 |
RPT193
|
|
|
|
RPT193 is an orally active CCR4 inhibitor that exhibits an inhibitory effect on the recruitment of Th2 inflammatory immune cells to inflammatory tissues and plays an important role in diseases such as atopic dermatitis, ... |
|
T22189 |
APC 366
|
|
|
|
APC 366 is a selective inhibitor of mast cell tryptase with Ki of 7.1 μM. APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep... |
|
T62860 |
YM-341619
|
|
|
|
YM-341619 (AS1617612) is a potent, orally active STAT6 inhibitor (IC50: 0.70 nM). YM-341619 inhibits IL-4-induced Th2 differentiation in mouse splenic T cells with an IC50 value of 0.28 nM, but does not affect Th1 cell d... |
|
T35836 |
PMX-205 (trifluoroacetate salt)
|
|
|
|
PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3... |
|
T75806 |
Lyn peptide inhibitor TFA
|
|
|
|
Lyn Peptide Inhibitor TFA is a powerful, cell-permeable inhibitor specifically targeting the Lyn-coupled IL-5 receptor signaling pathway, without affecting alternative signaling pathways. It effectively prevents Lyn acti... |
|
T37620 |
Leukotriene C4 methyl ester
|
|
|
|
Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular met... |
|
T74583 |
Desmethylazelastine
|
|
|
|
Desmethylazelastine, the primary active metabolite of Azelastine, undergoes oxidative metabolism via the cytochrome P450 enzyme system, exhibits a 97% protein binding rate, and has an elimination half-life of 54 hours. A... |
|
T35457 |
(±)12(13)-DiHOME
|
(±)12(13)-DiHOME,Isoleukotoxin diol |
|
|
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME , a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin. [1] It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils... |
|
T76942 |
Cendakimab
|
|
|
|
Cendakimab (RPC4046; ABT 308; CC-93538) is a selective humanized recombinant monoclonal antibody targeting the IL-13 molecule with high specificity. It demonstrates potent affinity for both the wild-type and variant form... |
